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Title: Pyrabactin  
Author: World Heritage Encyclopedia
Language: English
Subject: Abscisic acid
Publisher: World Heritage Encyclopedia


CAS number 419538-69-5
PubChem 1125790
ChemSpider 958087
Jmol-3D images Image 1
Molecular formula C16H13BrN2O2S
Molar mass 377.26 g mol−1
Appearance White to off-white powder[1]
Solubility in DMSO >10 mg/mL[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pyrabactin is a synthetic sulfonamide that mimics abscisic acid (ABA), a naturally produced stress hormone in plants that helps them cope with drought conditions by inhibiting growth. ABA can be manufactured for agricultural use; however, ABA is light-sensitive and costly to make. Pyrabactin is relatively inexpensive, easy to make, and not sensitive to light. Unlike ABA, pyrabactin activates only a few of the 14 ABA receptors in the plant needed for effective drought tolerance.[2] Its role as an ABA mimic may make pyrabactin an important tool for protecting crops against drought and cold weather.[3][4]

The discovery of pyrabactin by Sean Cutler was named a breakthrough research of 2009 by Science magazine.[5]

Pyrabactin (for pyridyl containing ABA activator) is a naphthalene sulfonamide hypocotyl cell expansion inhibitor. A combination of genetic, transcriptomic and physiological evidence demonstrated that pyrabactin activates the ABA pathway in a manner very similar to ABA. As such, pyrabactin is the first ABA agonist that is not an ABA analog and may ultimately lead to the development of a new family of synthetic plant growth regulators.


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