World Library  
Flag as Inappropriate
Email this Article

Howell-Jolly bodies

Article Id: WHEBN0016525906
Reproduction Date:

Title: Howell-Jolly bodies  
Author: World Heritage Encyclopedia
Language: English
Subject: Hereditary spherocytosis, Inclusion bodies, Micronucleus
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Howell-Jolly bodies


Howell–Jolly bodies are histopathological findings of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow erythrocytes normally expel their nuclei, but in some cases a small portion of DNA remains. Its presence usually signifies a damaged spleen.

It is named for William Henry Howell and Justin Marie Jolly.[1][2][3]

Appearance

This DNA appears as a basophilic (purple) spot on the otherwise eosinophilic (pink) erythrocyte on a standard H&E stained blood smear. These inclusions are normally pitted out by the spleen during erythrocyte circulation, but will persist in individuals with functional hyposplenia or asplenia.

Causes

Howell-Jolly bodies are seen with markedly decreased splenic function. Common causes include asplenia splenectomy, trauma to the spleen, and autosplenectomy caused by sickle cell anemia. Ten percent of patients with Celiac disease also present with splenic atrophy with subsequent Howell–Jolly bodies. Other causes are radiation therapy involving the spleen, such as that used to treat Hodgkin lymphoma. Howell–Jolly bodies are also seen in: severe hemolytic anemia, megaloblastic anemia, hereditary spherocytosis, and myelodysplastic syndrome (MDS).

References

External links

  • Digital Pathology, Brown University: Howell-Jolly Bodies
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.