World Library  
Flag as Inappropriate
Email this Article

Frontier molecular orbital theory

Article Id: WHEBN0022629003
Reproduction Date:

Title: Frontier molecular orbital theory  
Author: World Heritage Encyclopedia
Language: English
Subject: Inverse electron-demand Diels–Alder reaction, Theory, Index of physics articles (F)
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Frontier molecular orbital theory

In chemistry, frontier molecular orbital theory is an application of MO theory describing HOMO / LUMO interactions.

History

In 1952, Robert Burns Woodward entitled, "The Conservation of Orbital Symmetry."

Fukui's own work looked at the frontier orbitals, and in particular the effects of the Highest Occupied Molecular Orbital (HOMO) and the Lowest Unoccupied Molecular Orbital (LUMO) on reaction mechanisms, which led to it being called Frontier Molecular Orbital Theory (FMO Theory). He used these interactions to better understand the conclusions of the Woodward–Hoffmann rules.

Theory

Fukui realized that a good approximation for reactivity could be found by looking at the frontier orbitals (HOMO/LUMO). This was based on three main observations of molecular orbital theory as two molecules interact:

  1. The occupied orbitals of different molecules repel each other.
  2. Positive charges of one molecule attract the negative charges of the other.
  3. The occupied orbitals of one molecule and the unoccupied orbitals of the other (especially the HOMO and LUMO) interact with each other causing attraction.

From these observations, frontier molecular orbital (FMO) theory simplifies reactivity to interactions between the HOMO of one species and the LUMO of the other. This helps to explain the predictions of the Woodward–Hoffmann rules for thermal pericyclic reactions, which are summarized in the following statement:

"A ground-state pericyclic change is symmetry-allowed when the total number of (4q+2)s and (4r)a components is odd"

(4q+2)s refers to the number of aromatic, suprafacial electron systems; likewise, (4r)a refers to antiaromatic, antarafacial systems. It can be shown that if the total number of these systems is odd then the reaction is thermally allowed.[2]

Applications

Cycloadditions

A cycloaddition is a reaction that simultaneously forms at least two new bonds, and in doing so, converts two or more open-chain molecules into rings.[3] The transition states for these reactions typically involves the electrons of the molecules moving in continuous rings, making it a pericyclic reaction. These reactions can be predicted by the Woodward–Hoffmann rules and thus are closely approximated by FMO Theory.

The Diels–Alder reaction between maleic anhydride and cyclopentadiene is allowed by the Woodward–Hoffmann rules because there are six electrons moving suprafacially and no electrons moving antarafacially. Thus, there is one (4q + 2)s component and no (4r)a component, which means the reaction is allowed thermally.

FMO theory also finds that this reaction is allowed and goes even further by predicting its stereoselectivity, which is unknown under the Woodward-Hoffmann rules. Since this is a [4 + 2], the reaction can be simplified by considering the reaction between butadiene and ethene. The HOMO of butadiene and the LUMO of ethene are both antisymmetric (rotationally symmetric), meaning the reaction is allowed.*

In terms of the stereoselectivity of the reaction between maleic anhydride and cyclopentadiene, the endo-product is favored, a result best explained through FMO theory. The maleic anhydride is an electron-withdrawing species that makes the dieneophile electron deficient, forcing the regular Diels–Alder reaction. Thus, only the reaction between the HOMO of cyclopentadiene and the LUMO of maleic anhydride is allowed. Furthermore, though the exo-product is the more thermodynamically stable isomer, there are secondary (non-bonding) orbital interactions in the endo- transition state, lowering its energy and making the reaction towards the endo- product faster, and therefore more kinetically favorable. Since the exo-product has primary (bonding) orbital interactions it can still form, but since the endo-product forms faster it is the major product.[2]

*Note: The HOMO of ethene and the LUMO of butadiene are both symmetric, meaning the reaction between these species is allowed as well. This is referred to as the "inverse electron demand Diels–Alder."

Sigmatropic reactions

A sigmatropic rearrangement is a reaction in which a sigma bond moves across a conjugated pi system with a concomitant shift in the pi bonds. The shift in the sigma bond may be antarafacial or suprafacial. In the example of a [1,5] shift in pentadiene, if there is a suprafacial shift, there is 6 e moving suprafacially and none moving antarafacially, implying this reaction is allowed by the Woodward–Hoffmann rules. For an antarafacial shift, the reaction is not allowed.

These results can be predicted with FMO theory by observing the interaction between the HOMO and LUMO of the species. To use FMO theory, the reaction should be considered as two separate ideas: (1) whether or not the reaction is allowed, and (2) which mechanism the reaction proceeds though. In the case of a [1,5] shift on pentadiene, the HOMO of the sigma bond (i.e. a constructive bond) and the LUMO of butadiene on the remaining 4 carbons is observed. Assuming the reaction happens suprafacially, the shift results with the HOMO of butadiene on the 4 carbons that are not involved in the sigma bond of the product. Since the pi system changed from the LUMO to the HOMO, this reaction is allowed (though it would not be allowed if the pi system went from LUMO to LUMO).

To explain why the reaction happens suprafacially, first notice that the terminal orbitals are in the same phase. For there to be a constructive sigma bond formed after the shift, the reaction would have to be suprafacial. If the species shifted antarafacially then it would form an antibonding orbital and there would not be a constructive sigma shift.

It is worth noting that in propene the shift would have to be antarafacial, but since the molecule is very small that twist is not possible and the reaction is not allowed.

Electrocyclic reactions

An electrocyclic reaction is a pericyclic reaction involving the net loss of a pi bond and creation of a sigma bond with formation of a ring. This reaction proceeds through either a conrotatory or disrotatory mechanism. In the conrotatory ring opening of cyclobutene, there are two electrons moving suprafacially (on the pi bond) and two moving antarafacially (on the sigma bond). This means there is one 4q + 2 suprafacial system and no 4r antarafacial system; thus the conrotatory process is thermally allowed by the Woodward–Hoffmann rules.

The HOMO of the sigma bond (i.e. a constructive bond) and the LUMO of the pi bond are important in the FMO theory consideration. If the ring opening uses a conrotatory process then the reaction results with the HOMO of butadiene. As in the previous examples the pi system moves from a LUMO species to a HOMO species, meaning this reaction is allowed.[2]

See also

References

  1. ^ Fukui, Kenichi; Yonezawa, Teijiro; Shingu, Haruo (1952). "A Molecular Orbital Theory of Reactivity in Aromatic Hydrocarbons". The Journal of Chemical Physics 20 (4): 722.  
  2. ^ a b c  
  3. ^ Miller, Bernard (2004). Advanced Organic Chemistry: Reactions and Mechanisms. Upper Saddle River, NJ: Pearsons. pp. 53–54.  
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.