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Title: Cenpf  
Author: World Heritage Encyclopedia
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Subject: FOXM1, Long non-coding RNA, Telomere-binding protein, DbCRID, CENPI
Publisher: World Heritage Encyclopedia


Centromere protein F, 350/400kDa
Symbols  ; CENF; PRO1779; hcp-1
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Centromere protein F is a protein that in humans is encoded by the CENPF gene.[1][2][3] This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.[3]


  1. ^ Rattner JB, Rao A, Fritzler MJ, Valencia DW, Yen TJ (Mar 1994). "CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization".  
  2. ^ Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics 23 (3): 691–3.  
  3. ^ a b "Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)". 

Further reading

  • Ma L, Zhao X, Zhu X (2006). "Mitosin/CENP-F in mitosis, transcriptional control, and differentiation.". J. Biomed. Sci. 13 (2): 205–13.  
  • Liao H, Winkfein RJ, Mack G, et al. (1995). "CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.". J. Cell Biol. 130 (3): 507–18.  
  • Li Q, Ke Y, Kapp JA, et al. (1995). "A novel cell-cycle-dependent 350-kDa nuclear protein: C-terminal domain sufficient for nuclear localization.". Biochem. Biophys. Res. Commun. 212 (1): 220–8.  
  • Zhu X, Chang KH, He D, et al. (1995). "The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization.". J. Biol. Chem. 270 (33): 19545–50.  
  • Zhu X, Mancini MA, Chang KH, et al. (1995). "Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression.". Mol. Cell. Biol. 15 (9): 5017–29.  
  • Li S, Ku CY, Farmer AA, et al. (1998). "Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.". J. Biol. Chem. 273 (11): 6183–9.  
  • Chan GK, Schaar BT, Yen TJ (1998). "Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.". J. Cell Biol. 143 (1): 49–63.  
  • Zhu X (1999). "Structural requirements and dynamics of mitosin-kinetochore interaction in M phase.". Mol. Cell. Biol. 19 (2): 1016–24.  
  • Erlanson M, Casiano CA, Tan EM, et al. (1999). "Immunohistochemical analysis of the proliferation associated nuclear antigen CENP-F in non-Hodgkin's lymphoma.". Mod. Pathol. 12 (1): 69–74.  
  • Goodwin RL, Pabón-Peña LM, Foster GC, Bader D (1999). "The cloning and analysis of LEK1 identifies variations in the LEK/centromere protein F/mitosin gene family.". J. Biol. Chem. 274 (26): 18597–604.  
  • Ashar HR, James L, Gray K, et al. (2000). "Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.". J. Biol. Chem. 275 (39): 30451–7.  
  • Kobayashi M, Hanai R (2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes.". Biochem. Biophys. Res. Commun. 287 (1): 282–7.  
  • Hussein D, Taylor SS (2003). "Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis.". J. Cell. Sci. 115 (Pt 17): 3403–14.  
  • Holstein SA, Hohl RJ (2003). "Synergistic interaction of lovastatin and paclitaxel in human cancer cells.". Mol. Cancer Ther. 1 (2): 141–9.  
  • Konstantinidou AE, Korkolopoulou P, Kavantzas N, et al. (2003). "Mitosin, a novel marker of cell proliferation and early recurrence in intracranial meningiomas.". Histol. Histopathol. 18 (1): 67–74.  
  • Yang ZY, Guo J, Li N, et al. (2004). "Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport.". Cell Res. 13 (4): 275–83.  
  • Laoukili J, Kooistra MR, Brás A, et al. (2005). "FoxM1 is required for execution of the mitotic programme and chromosome stability.". Nat. Cell Biol. 7 (2): 126–36.  
  • Zhou X, Wang R, Fan L, et al. (2005). "Mitosin/CENP-F as a negative regulator of activating transcription factor-4.". J. Biol. Chem. 280 (14): 13973–7.  
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