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Title: Tinf2  
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Subject: Shelterin, Telomeres, Telomere-binding protein, DbCRID, CENPI
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TERF1 (TRF1)-interacting nuclear factor 2

Rendering based on PDB .
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; DKCA3; TIN2
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.[1][2] TIN2 is a component of the shelterin protein complex found at the end of telomeres.[3]


TINF2 has been shown to interact with ACD,[4][5] POT1[4][5][6] and TERF1.[1][5][7]


  1. ^ a b Kim SH, Kaminker P, Campisi J (Dec 1999). "TIN2, a new regulator of telomere length in human cells". Nat Genet 23 (4): 405–12.  
  2. ^ "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2". 
  3. ^ Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008). "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". Am J Hum Genet 82 (2): 501–9.  
  4. ^ a b Ye, Jeffrey Zheng-Sheng; Hockemeyer Dirk; Krutchinsky Andrew N; Loayza Diego; Hooper Sarah M; Chait Brian T; de Lange Titia (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes Dev. (United States) 18 (14): 1649–54.  
  5. ^ a b c Liu, Dan; Safari Amin, O'Connor Matthew S, Chan Doug W, Laegeler Andrew, Qin Jun, Songyang Zhou (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nat. Cell Biol. (England) 6 (7): 673–80.  
  6. ^ Loayza, Diego; De Lange Titia (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control".  
  7. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68.  

Further reading

External links

  • GeneReviews/NCBI/NIH/UW entry on Dyskeratosis Congenita

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