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Title: Scabies  
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Subject: Sexually transmitted infection, List of infectious diseases, Bed bug infestation, Dermatitis herpetiformis, Syphilis
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Classification and external resources
A photomicrograph of an itch mite (Sarcoptes scabiei)
ICD-10 B86
ICD-9 133.0
DiseasesDB 11841
MedlinePlus 000830
eMedicine derm/382 emerg/517 ped/2047
Patient UK Scabies
MeSH D012532

Scabies (from Latin: scabere, "to scratch"),[1] also known colloquially as the seven-year itch,[2] is a contagious skin infection caused by the mite Sarcoptes scabiei. The mite is a tiny, and usually not directly visible, parasite which burrows under the host's skin, which in most people causes an intense itching sensation caused by an allergic response. The infection in animals other than humans is caused by a different but related mite species, and is called sarcoptic mange.

Scabies is classified by the [3] The disease may be transmitted from objects, but is most often transmitted by direct skin-to-skin contact, with a higher risk with prolonged contact. Initial infections require four to six weeks to become symptomatic. Reinfection, however, may manifest symptoms within as few as 24 hours. Because the symptoms are allergic, their delay in onset is often mirrored by a significant delay in relief after the parasites have been eradicated. Crusted scabies, formerly known as Norwegian scabies, is a more severe form of the infection often associated with immunosuppression. Scabies is one of the three most common skin disorders in children, along with tinea and pyoderma.[4] As of 2010 it affects approximately 100 million people (1.5% of the world population) and is equally common in both sexes.[5]

Signs and symptoms

The characteristic symptoms of a scabies infection include intense itching and superficial burrows.[6] The burrow tracks are often linear, to the point that a neat "line" of four or more closely placed and equally developed mosquito-like "bites" is almost diagnostic of the disease.


In the classic scenario, the itch is made worse by warmth, and is usually experienced as being worse at night, possibly because there are fewer distractions.[6] As a symptom, it is less common in the elderly.[6]


Commonly involved sites of rashes of scabies[7]

The superficial burrows of scabies usually occur in the area of the hands, feet, wrists, elbows, back, buttocks, and external genitals.[6] Except in infants and the immunosuppressed, infection generally does not occur in the skin of the face or scalp. The burrows are created by excavation of the adult mite in the epidermis.[6]

In most people, the trails of the burrowing mites are linear or s-shaped tracks in the skin often accompanied by rows of small, pimple-like mosquito or insect bites. These signs are often found in crevices of the body, such as on the webs of fingers and toes, around the genital area, and under the breasts of women.[8]

Symptoms typically appear two to six weeks after infestation for individuals never before exposed to scabies. For those having been previously exposed, the symptoms can appear within several days after infestation. However, it is not unknown for symptoms to appear after several months or years.[9] Acropustulosis, or blisters and pustules on the palms and soles of the feet, are characteristic symptoms of scabies in infants.[8]

Crusted scabies

Crusted scabies in a person with AIDS

The elderly and people with an impaired immune system, such as HIV, cancer, or those on immunosuppressive medications, are susceptible to crusted scabies (formerly called Norwegian scabies).[6][9][10] On those with weaker immune systems, the host becomes a more fertile breeding ground for the mites, which spread over the host's body, except the face. Sufferers of crusted scabies exhibit scaly rashes, slight itching, and thick crusts of skin that contain thousands of mites.[11] Such areas make eradication of mites particularly difficult, as the crusts protect the mites from topical miticides, necessitating prolonged treatment of these areas.


Video of the Sarcoptes scabiei mite
Video of the Sarcoptes scabiei mite

Video of the Sarcoptes scabiei mite
Life cycle of scabies[7]

In the 18th century, Italian biologist Arachnida) as spiders and ticks.

Sarcoptes scabiei mites are under 0.5 mm in size but are sometimes visible as pinpoints of white. Pregnant females tunnel into the dead, outermost layer (stratum corneum) of a host's skin and deposit eggs in the shallow burrows. The eggs hatch into larvae in three to ten days. These young mites move about on the skin and molt into a "nymphal" stage, before maturing as adults, which live three to four weeks in the host's skin. Males roam on top of the skin, occasionally burrowing into the skin. In general, few mites usually occur on a healthy hygienic person infested with noncrusted scabies; about 11 females in burrows can be found on such a person.[12]

The movement of mites within and on the skin produces an intense itch, which has the characteristics of a delayed cell-mediated inflammatory response to allergens. IgE antibodies are present in the serum and the site of infection, which react to multiple protein allergens in the body of the mite. Some of these cross-react to allergens from house-dust mites. Immediate antibody-mediated allergic reactions (wheals) have been elicited in infected persons, but not in healthy persons; immediate hypersensitivity of this type is thought to explain the observed far more rapid allergic skin response to reinfection seen in persons having been previously infected (especially having been infected within the previous year or two).[13] Because the host develops the symptoms as a reaction to the mites' presence over time, usually a four- to six-week incubation period after the onset of infestation is found. As noted, those previously infected with scabies and cured may exhibit the symptoms of a new infection in a much shorter period, as little as one to four days.[14]

Scabies is [18]


The symptoms are caused by an allergic reaction of the host's body to mite proteins, though exactly which proteins remains a topic of study. The mite proteins are also present from the gut, in mite feces, which are deposited under the skin. The allergic reaction is both of the delayed (cell-mediated) and immediate (antibody-mediated) type, and involves IgE (antibodies, it is presumed, mediate the very rapid symptoms on reinfection).[12] The allergy-type symptoms (itching) continue for some days, and even several weeks, after all mites are killed. New lesions may appear for a few days after mites are eradicated. Nodular lesions from scabies may continue to be symptomatic for weeks after the mites have been killed.[12]


Magnified view of a burrowing trail of the scabies mite: The scaly patch on the left was caused by the scratching and marks the mite's entry point into the skin. The mite has burrowed to the top-right, where it can be seen as a dark spot at the end.

Scabies may be diagnosed clinically in geographical areas where it is common when diffuse itching presents along with either lesions in two typical spots or there is itchiness of another household member.[4] The classical sign of scabies is the burrows made by the mites within the skin.[4] To detect the burrow, the suspected area is rubbed with ink from a fountain pen or a topical tetracycline solution, which glows under a special light. The skin is then wiped with an alcohol pad. If the person is infected with scabies, the characteristic zigzag or S pattern of the burrow will appear across the skin; however, interpreting this test may be difficult, as the burrows are scarce and may be obscured by scratch marks.[4] A definitive diagnosis is made by finding either the scabies mites or their eggs and fecal pellets.[4] Searches for these signs involve either scraping a suspected area, mounting the sample in potassium hydroxide and examining it under a microscope, or using dermoscopy to examine the skin directly.[6]

Differential diagnosis

Symptoms of early scabies infestation mirror other skin diseases, including dermatitis, syphilis, various urticaria-related syndromes, allergic reactions, and other ectoparasites such as lice and fleas.[19]


Mass treatment programs that use topical permethrin or oral ivermectin have been effective in reducing the prevalence of scabies in a number of populations.[4] No vaccine is available for scabies. The simultaneous treatment of all close contacts is recommended, even if they show no symptoms of infection (asymptomatic), to reduce rates of recurrence.[4][4] Since mites can survive for only two to three days without a host, objects in the environment pose little risk of transmission except in the case of crusted scabies, thus cleaning is of little importance.[4] Rooms used by those with crusted scabies require thorough cleaning.[20]


A number of medications are effective in treating scabies; however, treatment must often involve the entire household or community to prevent reinfection.[4] Options to control itchiness include antihistamines.[21]


Permethrin is the most effective treatment for scabies,[22] and is the treatment of choice.[4][23] It is applied from the neck down, usually before bedtime, and left on for about eight to 14 hours, then washed off in the morning.[4] One application is normally sufficient for mild infections. For moderate to severe cases, another dose is typically applied seven to 14 days later.[4][23][24] Permethrin causes slight irritation of the skin, but the sensation is tolerable.[6] The medication, however, is the most costly of topical treatments.[6]


Ivermectin is an oral medication shown by many clinical studies to be effective in eradicating scabies, often in a single dose.[3][4] It is the treatment of choice for crusted scabies, and is often used in combination with a topical agent.[4][6] It has not been tested on infants and is not recommended for children under six years of age.[6]

Topical ivermectin preparations have been found to be effective for scabies in adults, and are attractive due to their low cost, ease of preparation, and low toxicity.[25] It has also been useful for sarcoptic mange (the veterinary analog of human scabies).[26]


Other treatments include lindane, benzyl benzoate, crotamiton, malathion, and sulfur preparations.[4][6] Lindane is effective, but concerns over potential neurotoxicity has limited its availability in many countries.[6] It is approved in the United States for use as a second-line treatment.[27] Sulfur ointments or benzyl benzoate are often used in the developing world due to their low cost;[6] 10% sulfur solutions have been shown to be effective,[28] and sulfur ointments are typically used for at least a week.[6] Crotamiton has been found to be less effective than permethrin in limited studies.[6] Crotamiton or a sulfur preparation is often recommended instead of permethrin for children, due to concerns over dermal absorption of permethrin.[4]


Anne Frank was infected with scabies at Bergen-Belsen concentration camp,[29] and scabies is endemic in many developing countries,[30] where it tends to be particularly problematic in rural and remote areas. In such settings community wide control strategies are required to reduce the rate of disease, as treatment of only individuals is ineffective due to the high rate of reinfection. Large-scale mass drug administration strategies may be required where coordinated interventions aim to treat whole communities in one concerted effort.[31] Although such strategies have shown to be able to reduce the burden of scabies in these kinds of communities, debate remains about the best strategy to adopt, including the choice of drug.[31][32]

The resources required to implement such large-scale interventions in a cost-effective and sustainable way are significant. Furthermore, since endemic scabies is largely restricted to poor and remote areas, it is a public health issue that has not attracted much attention from policy makers and international donors.[31][32]


Scabies is one of the three most common skin disorders in children, along with tinea and pyoderma.[4] As of 2010 it affects approximately 100 million people (1.5% of the population) and is equally common in both genders.[5] The mites are distributed around the world and equally infect all ages, races, and socioeconomic classes in different climates.[11] Scabies is more often seen in crowded areas with unhygienic living conditions.[33] Globally as of 2009, an estimated 300 million cases of scabies occur each year, although various parties claim the figure is either over- or underestimated.[9][34] About 1–10% of the global population is estimated to be infected with scabies, but in certain populations, the infection rate may be as high as 50–80%.[4]


Wax figurine of a man with Norwegian scabies

Scabies has been seen in humans since ancient time. Archeological evidence from Egypt and the Middle East suggests scabies was present as early as 494 BC.[14][35] The first recorded reference to scabies is believed to be from the Bible – it may be a type of "leprosy" mentioned in Leviticus circa 1200 BC[36] or be mentioned among the curses of Deuteronomy 28.[37] Later, in the fourth century BC, the ancient Greek philosopher and naturalist Aristotle reported on "lice" that "escape from little pimples if they are pricked";[38] scholars believe this was actually a reference to scabies.

Nevertheless, Greek physician Celsus is credited with naming the disease "scabies" and describing its characteristic features.[38] The parasitic etiology of scabies was later documented by the Italian physician Giovanni Cosimo Bonomo (1663–99 AD) in his famous 1687 letter, "Observations concerning the fleshworms of the human body".[38] With this discovery, scabies became one of the first diseases with a known cause.[14][35]

Society and culture

The International Alliance for the Control of Scabies was started in 2012,[32][39][40] and brings together over 70 researchers, clinicians and public health experts from more than 15 different countries. It has managed to bring the global health implications of scabies to the attention of the [32] Consequently, the WHO has included scabies on its official list of neglected tropical diseases and other neglected conditions.[41]

Other animals

A street dog in Bali, Indonesia, suffers from sarcoptic mange.

Scabies may occur in a number of domestic and wild animals; the mites that cause these infestations are of different subspecies.[6] These subspecies can infest animals or humans that are not their usual hosts, but such infections do not last long.[6] Scabies-infected animals suffer severe itching and secondary skin infections. They often lose weight and become frail.[12]

The most frequently diagnosed form of scabies in domestic animals is sarcoptic mange, which is found on dogs. This disease is caused by the subspecies Sarcoptes scabiei canis. Scabies-infected domestic fowl suffer what is known as "scaly leg". Domestic animals that have gone feral and have no veterinary care are frequently afflicted with scabies and a host of other ailments.[42] Nondomestic animals have also been observed to suffer from scabies. Gorillas, for instance, are known to be susceptible to infection via contact with items used by humans.[43]


  1. ^ Mosby's Medical, Nursing & Allied Health Dictionary, Fourth Edition, Mosby-Year Book Inc., 1994, p. 1395
  2. ^ Gates, Robert H. (2003). Infectious disease secrets (2. ed.). Philadelphia: Elsevier, Hanley Belfus. p. 355.  
  3. ^ a b "WHO -Water-related Disease". World Health Organization. Retrieved 2010-10-10. 
  4. ^ a b c d e f g h i j k l m n o p q r s Andrews RM, McCarthy J, Carapetis JR, Currie BJ (December 2009). "Skin disorders, including pyoderma, scabies, and tinea infections". Pediatr. Clin. North Am. 56 (6): 1421–40.  
  5. ^ a b Vos, T (Dec 15, 2012). "Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010.". Lancet 380 (9859): 2163–96.  
  6. ^ a b c d e f g h i j k l m n o p q r Hay RJ (2009). "Scabies and pyodermas—diagnosis and treatment". Dermatol Ther 22 (6): 466–74.  
  7. ^ a b CDC web site > DPDx - Laboratory Identification of Parasites of Public Health Concern > Scabies [1]
  8. ^ a b "Scabies". DermNet NZ. New Zealand Dermatological Society Incorporated. 
  9. ^ a b c Bouvresse, S.; Chosidow, O. (Apr 2010). "Scabies in healthcare settings". Curr Opin Infect Dis 23 (2): 111–8.  
  10. ^ Hicks MI, Elston DM (2009). "Scabies". Dermatol Ther 22 (4): 279–92.  
  11. ^ a b "DPDx—Scabies". Laboratory Identification of Parasites of Public Health Concern. CDC. 
  12. ^ a b c d Walton, SF; Currie, BJ (April 2007). "Problems in Diagnosing Scabies, a Global Disease in Human and Animal Populations". Clinical Microbiology Reviews 20 (2): 268–79.  
  13. ^ Clinical Microbiology Reviews, April 2007, p. 268-279, Vol. 20, No. 2 0893-8512/07/$08.00+0 Problems in Diagnosing Scabies, a Global Disease in Human and Animal Populations online referencedoi:10.1128/CMR.00042-06 PMID 17428886
  14. ^ a b c Markell, Edward K.; John, David C.; Petri, William H. (2006). Markell and Voge's medical parasitology (9th ed.). St. Louis, Mo: Elsevier Saunders.  
  15. ^ Carol Turkington and Jeffrey S. Dover, M.D. (2006). The Encyclopedia of Skin and Skin Disorders. New York: Facts on File inc.  
  16. ^ Causes "Scabies Causes". WebMD. October 2010. Retrieved 2010-10-09. 
  17. ^ Chosidow O (April 2006). "Clinical practices. Scabies". N. Engl. J. Med. 354 (16): 1718–27.  
  18. ^ "Scabies—Fast Facts". American Social Health Association. Retrieved 2010-10-09. 
  19. ^ Arlian, LG (1989). "Biology, host relations, and epidemiology of Sarcoptes scabiei". Annual review of entomology 34: 139–61.  
  20. ^ "CDC—Prevention and Control—Scabies". Center for Disease Control and Prevention. Retrieved 2010-10-09. 
  21. ^ Vañó-Galván, S; Moreno-Martin, P (2008). "Generalized pruritus after a beach vacation. Diagnosis: scabies". Cleveland Clinic journal of medicine 75 (7): 474, 478.  
  22. ^ Strong M, Johnstone PW (2007). Strong, Mark, ed. "Interventions for treating scabies". Cochrane Database Syst Rev (3): CD000320.  
  23. ^ a b "Scabies". Illinois Department of Public Health. January 2008. Retrieved 2010-10-07. 
  24. ^ The Pill Book. Bantam Books. 2010. pp. 867–869.  
  25. ^ Victoria J, Trujillo R (2001). "Topical ivermectin: a new successful treatment for scabies". Pediatr Dermatol 18 (1): 63–5.  
  26. ^ "Parasitology Research, Volume 78, Number 2". SpringerLink. Retrieved 2010-11-14. 
  27. ^ "FDA Public Health Advisory: Safety of Topical Lindane Products for the Treatment of Scabies and Lice". 2009-04-30. Retrieved 2010-11-14. 
  28. ^ Jin-Gang A, Sheng-Xiang X, Sheng-Bin X, et al. (March 2010). "Quality of life of patients with scabies". J Eur Acad Dermatol Venereol 24 (10): 1187–91.  
  29. ^ Müller, Melissa (1999) [1998]. Das Mädchen Anne Frank [Anne Frank: The Biography] (in German). Kimber, Rita and Robert (translators). New York: Henry Holt and Company. ISBN 978-0-7475-4523-1. OCLC 42369449.; With a note from Miep Gies. Pp. 246-247.
  30. ^ Andrews, RM; McCarthy, J; Carapetis, JR; Currie, BJ (Dec 2009). "Skin disorders, including pyoderma, scabies, and tinea infections.". Pediatric clinics of North America 56 (6): 1421–40.  
  31. ^ a b c Hay, RJ; Steer, AC; Chosidow, O; Currie, BJ (Apr 2013). "Scabies: a suitable case for a global control initiative.". Current opinion in infectious diseases 26 (2): 107–9.  
  32. ^ a b c d Engelman, D; Kiang, K; Chosidow, O; McCarthy, J; Fuller, C; Lammie, P; Hay, R; Steer, A; Members Of The International Alliance For The Control Of, Scabies (2013). "Toward the global control of human scabies: introducing the International Alliance for the Control of Scabies.". PLoS neglected tropical diseases 7 (8): e2167.  
  33. ^ Green MS (1989). "Epidemiology of scabies". Epidemiol Rev 11 (1): 126–50.  
  34. ^ Hicks, MI; Elston, DM (Jul–Aug 2009). "Scabies". Dermatologic therapy 22 (4): 279–92.  
  35. ^ a b "Scabies homepage". Stanford University. Retrieved 2010-10-09. 
  36. ^ Leviticus 13:29-13:37
  37. ^ See translations
  38. ^ a b c Roncalli RA (July 1987). "The history of scabies in veterinary and human medicine from biblical to modern times". Vet. Parasitol. 25 (2): 193–8.  
  39. ^ "Scabies". Neglected tropical diseases. World Health Organization. Retrieved 1 February 2014. 
  40. ^ "International Alliance for the Control of Scabies". International Alliance for the Control of Scabies. Retrieved 1 February 2014. 
  41. ^ "The 17 neglected tropical diseases". Neglected tropical diseases. World Health Organization. Retrieved 1 February 2014. 
  42. ^ "Bali Animal Welfare Association". Retrieved 2009-07-28. 
  43. ^ "Uganda: Out of the Wild". Frontline. PBS. Retrieved Nov 4, 2013.

External links

  • American Academy of Dermatology pamphlet on Scabies
  • Scabies FAQ from the National Pediculosis Association
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