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Homologous chromosome

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Title: Homologous chromosome  
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Subject: Ploidy, Homologous recombination, Autosome, Sex-determination system, Chromosome
Collection: Chromosomes
Publisher: World Heritage Encyclopedia

Homologous chromosome

As this karyotype displays, a diploid human cell contains 23 pairs of homologous chromosomes. The cell has two sets of each chromosome; one of the pair is derived from the mother and the other from the father. The maternal and paternal chromosomes in a homologous pair have the same genes at the same loci, but possibly different alleles.

A couple of homologous chromosomes, or homologs, are a set of one maternal and one paternal offspring.[2]


  • Overview 1
  • History 2
  • Structure 3
    • In humans 3.1
  • Functions 4
    • In meiosis 4.1
      • Prophase I 4.1.1
      • Metaphase I 4.1.2
      • Anaphase I 4.1.3
      • Meiosis II 4.1.4
    • In mitosis 4.2
  • Problems 5
    • Nondisjunction 5.1
    • Embryonic death 5.2
  • Other uses 6
  • Relevant research 7
  • See also 8
  • References 9
  • Further reading 10


Chromosomes are linear arrangements of condensed alleles on the homologous chromosomes may be different, resulting in different phenotypes of the same genes. This mixing of maternal and paternal traits is enhanced by crossing over during meiosis, wherein lengths of chromosomal arms and the DNA they contain within a homologous chromosome pair are exchanged with one another.[3]


Early in the 1900s test cross experiments, he revealed that, for a single parent, the alleles of genes near to one another along the length of the chromosome move together. Using this logic he concluded that the two genes he was studying were located on homologous chromosomes. Later on during the 1930s Harriet Creighton and Barbara McClintock were studying meiosis in corn cells and examining gene loci on corn chromosomes.[2] Creighton and McClintock discovered that the new allele combinations present in the offspring and the event of crossing over were directly related.[2] This proved intrachromosomal genetic recombination.[2]


Homologous chromosomes are chromosomes which contain the same genes in the same order along their chromosomal arms. There are two main properties of homologous chromosomes: the length of chromosomal arms and the placement of the centromere [4]

The actual length of the arm, in accordance with the gene locations, is critically important for proper alignment. Centromere placement can be characterized by four main arrangements, consisting of being either metacentric, submetacentric, telocentric, or acrocentric. Both of these properties are the main factors for creating structural homology between chromosomes. Therefore when two chromosomes of the exact structure exist, they are able to pair together to form homologous chromosomes.[5]

Since homologous chromosomes are not identical and do not originate from the same organism, they are different from sister chromatids. Sister chromatids result after DNA replication has occurred, and thus are identical, side-by-side duplicates of each other.[6]

In humans

  • Gilbert SF (2003). Developmental biolog. Sunderland, Mass.: Sinauer Associates.  
  • OpenStaxCollege (25 Apr 2013). "Meiosis". Rice University. 

Further reading

  1. ^ "Homologous chromosomes". 2. Philadelphia: Saunders/Elsevier. 2008. pp. 815, 821–822.  
  2. ^ a b c d e f g h i j k Griffiths JF, Gelbart WM, Lewontin RC, Wessler SR, Suzuki DT, Miller JH (2005). Introduction to Genetic Analysis. New York: W.H. Freeman and Co. pp. 34–40, 473–476, 626–629.  
  3. ^ Campbell NA, Reece JB (2002). Biology. San Francisco: Benjamin Cummings.  
  4. ^ a b c Klug, William S. (2012). Concepts of Genetics. Boston: Pearson. pp. 21–22. 
  5. ^ Klug, William; Michael Cummings; Charlotte Spencer; Michael Pallodino (2009). "Chromosome Mutations: Variation in chromosome number and arrangement". In Beth Wilbur. Concepts of Genetics (9 ed.). San Francisco, CA: Pearson Benjamin Cumming. pp. 213–214.  
  6. ^ a b c d e f Pollard TD, Earnshaw WC, Lippincott-Schwartz J (2008). Cell Biology (2 ed.). Philadelphia: Saunders/Elsevier. pp. 815, 821–822.  
  7. ^ a b c d e Lodish HF (2013). Molecular cell biolog. New York: W.H. Freeman and Co. pp. 355, 891.  
  8. ^ Gregory MJ. "The Biology Web". Clinton Community College – State University of New York. 
  9. ^ a b c d e f g Gilbert SF (2014). Developmental Biology. Sunderland, MA: Sinauer Associates, Inc. pp. 606–610.  
  10. ^ "The Cell Cycle & Mitosis Tutorial". The Biology Project. University of Arizona. Oct 2004. 
  11. ^ a b c Gerton JL, Hawley RS (June 2005). "Homologous chromosome interactions in meiosis: diversity amidst conservation". Nat. Rev. Genet. 6 (6): 477–87.  
  12. ^ a b c Tissot, Robert and Kaufman, Elliot. "Chromosomal Inheritance". Human Genetics. University of Illinois at Chicago. 
  13. ^ a b c Sargent RG, Brenneman MA, Wilson JH (January 1997). "Repair of site-specific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination" (PDF). Mol. Cell. Biol. 17 (1): 267–77.  
  14. ^ a b Kuzminov A (July 2001). "DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8461–8.  
  15. ^ Petukhova GV, Romanienko PJ, Camerini-Otero RD. The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis. Dev Cell. 2003 Dec;5(6):927-36. PubMed PMID 14667414.
  16. ^ González F, Georgieva D, Vanoli F, Shi ZD, Stadtfeld M, Ludwig T, Jasin M, Huangfu D (2013). "Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State". Cell Reports 3 (3): 651–660.  
  17. ^ Khanna KK, Jackson SP (2001). "DNA double-strand breaks: Signaling, repair and the cancer connection". Nature Genetics 27 (3): 247–254.  


See also

There is ongoing research concerning the ability of homologous chromosomes to repair double-strand DNA breaks. Researchers are investigating the possibility of exploiting this capability for regenerative medicine.[16] This medicine could be very prevalent in relation to cancer, as DNA damage is thought to be contributor to carcinogenesis. Manipulating the repair function of homologous chromosomes might allow for bettering a cell’s damage response system. While research has not yet confirmed the effectiveness of such treatment, it may become a useful therapy for cancer.[17]

Current and future research on the subject of homologous chromosome is heavily focused on the roles of various proteins during recombination or during DNA repair. In a recently published article by Pezza et al. the protein known as HOP2 is responsible for both homologous chromosome synapsis as well as double-strand break repair via homologous recombination. The deletion of HOP2 in mice has large repercussions in meiosis.[15] Other current studies focus on specific proteins involved in homologous recombination as well.

Relevant research

While the main function of homologous chromosomes is their use in nuclear division, they are also used in repairing double-strand breaks of DNA.[13] These double-stranded breaks typically occur in DNA that serve as template strands for DNA replication, and they are the result of mutation, replication errors or malfunctioning DNA.[14] Homologous chromosomes can repair this damage by aligning themselves with chromosomes of the same genetic sequence.[13] Once the base pairs have been matched and oriented correctly between the two strands, the homologous chromosomes perform a process that is very similar to recombination, or crossing over as seen in meiosis. Part of the intact DNA sequence overlaps with that of the damaged chromosome's sequence. Replication proteins and complexes are then recruited to the site of damage, allowing for repair and proper replication to occur.[14] Through this functioning, double-strand breaks can be repaired and DNA can function normally.[13]

Diagram of the general process for double-stranded break repair as well as synthesis-dependent strand annealing.

Other uses

If unequal genetic crossover occurs within the gametes involved in meiosis, then the resulting zygote may suffer unviability.[4] This is caused by events such as trisomy and monosomy because the cells are not able to develop normally with these characteristics. In other terms, one cell gains the proper amount of genetic material while the other cell lacks that material.[12] Consequently, these deformed cells may cause a spontaneous abortion because the zygote does not develop correctly.[12]

Embryonic death

Proper homologous chromosome separation in meiosis I is crucial for sister chromatid separation in meiosis II.[11] A failure to separate properly is known as nondisjunction. There are two main types of nondisjunction that occur: trisomy and monosomy. Trisomy is caused by the presence of one additional chromosomes in the zygote as compared to the normal number, and monosomy is characterized by the presence of a one less chromosome in the zygote as compared to the normal number. If this uneven division occurs in meiosis I, then none of the daughter cells will have proper chromosomal distribution and severe effects can ensue, including Down’s syndrome.[12] Unequal division can also occur during the second meiotic division. Nondisjunction which occurs at this stage can result in normal daughter cells and deformed cells.[4]


There are severe repercussions when chromosomes do not segregate properly. Faulty segregation can lead to genetic material to be sorted correctly.[11]

1. Meiosis I 2. Meiosis II 3. Fertilization 4. Zygote Nondisjunction is when chromosomes fail to separate normally resulting in a gain or loss of chromosomes. In the left image the ultra violet arrow indicates nondisjunction taking place during meiosis II. In the right image the green arrow is indicating nondisjunction taking place during meiosis I.


Homologous chromosomes do not function the same in mitosis as they do in meiosis. Prior to every single mitotic division a cell undergoes, the chromosomes in the parent cell replicate themselves. The homologous chromosomes within the cell will not pair up and undergo genetic recombination with each other.[9] Instead, the replicants, or sister chromatids, will line up along the metaphase plate and then separate in the same way as meiosis II - by being pulled apart at their centromeres by nuclear mitotic spindles.[10] If any crossing over does occur between sister chromatids during mitosis, it does not produce any recombinants.[2]

In mitosis

After the tetrads of homologous chromosomes are separated in meiosis I, the sister chromatids from each pair are separated. The two diploid daughter cells resulting from meiosis I undergo another cell division in meiosis II but without another round of chromosomal replication. The sister chromatids in the two daughter cells are pulled apart during anaphase II by nuclear spindle fibers, resulting in four haploid daughter cells.[2]

Meiosis II

In anaphase I of meiosis I the homologous chromosomes are pulled apart from each other. The homologs are cleaved by the enzyme separase to release the cohesin that held the homologous chromosome arms together.[7] This allows the chiasmata to release and the homologs to move to opposite poles of the cell.[7] The homologous chromosomes are now randomly segregated into two daughter cells that will undergo meiosis II to produce four haploid daughter germ cells.[2]

Anaphase I

In metaphase I of meiosis I, the pairs of homologous chromosomes, also known as bivalents or tetrads, line up in a random order along the metaphase plate.[9] The random orientation is another way for cells to introduce genetic variation. Meiotic spindles emanating from opposite spindle poles attach to each of the homologs (each pair of sister chromatids) at the kinetochore.[7]

Metaphase I

In prophase I of meiosis I, each chromosome is aligned with its homologous partner and pairs completely. In prophase I, the DNA has already undergone replication so each chromosome consists of two identical chromatids connected by a common centromere.[9] During the zygotene stage of prophase I, the homologous chromosomes pair up with each other.[9] This pairing occurs by a synapsis process where the synaptonemal complex - a protein scaffold - is assembled and joins the homologous chromosomes along their lengths.[6] Cohesin crosslinking occurs between the homologous chromosomes and helps them resist being pulled apart until anaphase.[7] Genetic crossing over occurs during the pachytene stage of prophase I.[9] In this process, genes are exchanged by the breaking and union of homologous portions of the chromosomes’ lengths.[6] Structures called chiasmata are the site of the exchange. Chiasmata physically link the homologous chromosomes once crossing over occurs and throughout the process of chromosomal segregation during meiosis.[6] At the diplotene stage of prophase I the synaptonemal complex disassembles before which will allow the homologous chromosomes to separate, while the sister chromatids stay associated by their centromeres.[6]

Prophase I

Meiosis is a round of two cell divisions that results in four haploid daughter cells that each contain half the number of chromosomes as the parent cell.[9] It reduces the chromosome number in a natural selection to act on.[2]

 Sorting of homologous chromosomes during meiosis
Sorting of homologous chromosomes during meiosis.

Depiction of chromosome 1 after undergoing homologous recombination in meiosis
During the process of meiosis, homologous chromosomes can recombine and produce new combinations of genes in the daughter cells.

In meiosis

Homologous chromosomes are important in the processes of meiosis and mitosis. They allow for the recombination and random segregation of genetic material from the mother and father into new cells.[8]



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