World Library  
Flag as Inappropriate
Email this Article

Chromosome 20 (human)

Article Id: WHEBN0003408012
Reproduction Date:

Title: Chromosome 20 (human)  
Author: World Heritage Encyclopedia
Language: English
Subject: Chromosomes, Human genome, Hepatocyte nuclear factors, Ring chromosome 20 syndrome, MODY 1
Collection: Chromosomes, Chromosomes (Human), Genes on Human Chromosome 20
Publisher: World Heritage Encyclopedia

Chromosome 20 (human)

Chromosome 20 (human)
Pair of human chromosome 20 (after G-banding).
One is from mother, one is from father.
Chromosome 20 pair in human male karyogram.
Length (bp) 63,025,520 bp[1]
Number of genes 897 (NCBI)
1,068 (EBI)
Type Autosome
Centromere position Metacentric [2]
RefSeq NC_000020
GenBank CM000682
Map of Chromosome 20
Ideogram of human chromosome 20. Mbp means mega base pair. See locus for other notation.

Chromosome 20 is one of the 23 pairs of chromosomes in humans. Chromosome 20 spans around 63 million base pairs (the building material of DNA) and represents between 2 and 2.5 percent of the total DNA in cells. Chromosome 20 was fully sequenced in 2001 and was reported to contain over 59 million base pairs representing 99.4% of the euchromatic DNA.[3] Since then, due to sequencing improvements and fixes, the length of chromosome 20 has been updated to just over 63 million base pairs.[1]

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Depending on the genome annotation used, chromosome 20 contains 897 or 1,068 genes.[4][5]


  • Genes 1
  • Diseases & disorders 2
  • References 3
  • External links 4


The following are some of the genes located on chromosome 20:

  • AHCY: S-adenosylhomocysteine hydrolase
  • ARFGEF2: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
  • BMP2: Bone Morphogenetic Protein 2 (osteoblast differentiation)
  • DNAJC5: Cysteine string protein
  • EDN3: endothelin 3
  • GSS: glutathione synthetase
  • GNAS1: Gs alpha subunit (membrane G-protein)
  • JAG1: jagged 1 (Alagille syndrome)
  • PANK2: pantothenate kinase 2 (Hallervorden-Spatz syndrome)
  • PRNP: prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
  • tTG: tissue transglutaminase (Celiac disease)
  • SALL4: sal-like 4 (Drosophila)
  • VAPB: VAMP (vesicle-associated membrane protein)-associated protein B and C

Diseases & disorders

The following diseases are some of those related to genes on chromosome 20:[6]


  1. ^ a b "Homo sapiens chromosome 20, GRCh37.p13 Primary Assembly". National Center for Biotechnology Information. Retrieved October 17, 2013. 
  2. ^ "Table 2.3: Human chromosome groups". Human Molecular Genetics (2nd ed.). Garland Science. 1999. 
  3. ^ Deloukas P; et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–871.  
  4. ^ "Map Viewer". National Center for Biotechnology Information. Retrieved October 17, 2013. 
  5. ^ "Vega Genome Browser 54: Homo sapiens - Chromosome summary - Chromosome 20: 1-62,965,520". Wellcome Trust Sanger Institute. Retrieved October 17, 2013. 
  6. ^ Gilbert F (1997). "Disease genes and chromosomes: disease maps of the human genome". Genet Test 1 (3): 225–229.  

External links

  • Human Chromosome 20 Map Viewer — on NCBI

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.