World Library  
Flag as Inappropriate
Email this Article

Bolivian hemorrhagic fever

 

Bolivian hemorrhagic fever

Machupo virus
Virus classification
Group: Group V ((-)ssRNA)
Family: Arenaviridae
Genus: Arenavirus
Species

Machupo virus

Bolivian hemorrhagic fever
Classification and external resources
Specialty Infectious disease
ICD-10 A96.1
ICD-9-CM 078.7
DiseasesDB 31899
MeSH D006478

Bolivian hemorrhagic fever (BHF), also known as black typhus or Ordog Fever, is a hemorrhagic fever and zoonotic infectious disease originating in Bolivia after infection by Machupo virus.[1]

BHF was first identified in 1963 as an ambisense RNA virus of the Arenaviridae family,[2][3] by a research group led by Karl Johnson. The mortality rate is estimated at 5 to 30 percent. Due to its pathogenicity, Machupo virus requires Biosafety Level Four conditions, the highest level.[4]

In February and March 2007, some 20 suspected BHF cases (3 fatal) were reported to the El Servicio Departamental de Salud (SEDES) in Beni Department, Bolivia, and in February 2008, at least 200 suspected new cases (12 fatal) were reported to SEDES.[5] In November 2011, a SEDES expert involved in a serosurvey to determine the extent of Machupo virus infections in the Department after the discovery of a second confirmed case near the departmental capital of Trinidad in November, 2011, expressed concern about expansion of the virus' distribution outside the endemic zone in Mamoré and Iténez provinces.[6][7]

Contents

  • Epidemiology 1
    • History 1.1
    • Vectors 1.2
    • Symptoms 1.3
    • Prevention 1.4
  • Weaponization 2
  • Vaccine Research 3
  • References 4
    • Bibliography 4.1

Epidemiology

History

The disease was first encountered in 1962, in the Bolivian village of San Joachim, hence the name "Bolivian" Hemorrhagic Fever. When initial investigations failed to find an arthropod carrier, other sources were sought before finally determining that the disease was carried by infected mice. Although mosquitoes were not the cause as originally suspected, the extermination of mosquitoes using DDT to prevent malaria proved to be indirectly responsible for the outbreak in that the accumulation of DDT in various animals along the food chain led to a shortage of cats in the village, subsequently a mouse plague erupted in the village leading to an epidemic.[8]

Vectors

The vector is the vesper mouse Calomys callosus, a rodent indigenous to northern Bolivia. Infected animals are asymptomatic and shed the virus in excreta, thereby infecting humans. Evidence of person-to-person transmission of BHF exists but is believed to be rare.[9]

Symptoms

The infection has a slow onset with fever, malaise, headache and muscular pains, very similar to Malaria symptoms. Petechiae (blood spots) on the upper body and bleeding from the nose and gums are observed when the disease progresses to the hemorrhagic phase, usually within seven days of onset.[9]

Prevention

Measures to reduce contact between the vesper mouse and humans may have contributed to limiting the number of outbreaks, with no cases identified between 1973 and 1994. Although there are no cures or vaccine for the disease, a vaccine developed for the genetically related Junín virus which causes Argentine hemorrhagic fever has shown evidence of cross-reactivity to Machupo virus, and may therefore be an effective prophylactic measure for people at high risk of infection. Post infection (and providing that the person survives the infection), those that have contracted BHF are usually immune to further infection of the disease.[9]

Weaponization

Bolivian hemorrhagic fever was one of three hemorrhagic fevers and one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its biological weapons program.[10] It was also under research by the Soviet Union, under the Biopreparat bureau.[11]

Vaccine Research

Investigational vaccines exist for Argentine hemorrhagic fever and RVF; however, neither is approved by FDA or commonly available in the United States.

References

  1. ^ Public Health Agency of Canada: Machupo Virus Pathogen Safety Data Sheet, http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/machupo-eng.php Date Modified: 2011-02-18.
  2. ^ "Machupo". Retrieved 2009-01-22. 
  3. ^ Webb PA, Johnson KM, Mackenzie RB, Kuns ML (July 1967). "Some characteristics of Machupo virus, causative agent of Bolivian hemorrhagic fever". Am. J. Trop. Med. Hyg. 16 (4): 531–8.  
  4. ^ Center for Food Security & Public Health and Institute for International Cooperation in Animal Biologics, Iowa State University: Viral Hemorrhagic Fevers Caused by Arenaviruses, http://www.cfsph.iastate.edu/Factsheets/pdfs/viral_hemorrhagic_fever_arenavirus.pdf last updated: February 23, 2010.
  5. ^ Aguilar PV, Carmago W, Vargas J, Guevara C, Roca Y, Felices V, et al. Reemergence of Bolivian hemorrhagic fever, 2007–2008 [letter]. Emerg Infect Dis [serial on the Internet] 2009 Sep. Available from http://wwwnc.cdc.gov/eid/article/15/9/09-0017.htm Accessed 2 Dec 2011.
  6. ^ "Caso confirmado de fiebre hemorrágica alerta a autoridades benianas," Los Tiempos.com, http://www.lostiempos.com/diario/actualidad/nacional/20111116/caso-confirmado-de-fiebre-hemorragica-alerta-a-autoridades_149655_310330.html 16/11/2011.
  7. ^ "SEDES movilizado para controlar brote de fiebre hemorrágica en Beni; También se Capacita a Los Comunarios y Estudiantes," Lost Tiempos.com, http://www.lostiempos.com/diario/actualidad/nacional/20111130/sedes-movilizado-para-controlar-brote-de-fiebre-hemorragica-en_151529_314539.html 30/11/2011.
  8. ^ Medical Microbiology 2nd edition; Mims et al. Mosby publishing 1998, p 371
  9. ^ a b c Kilgore, et al., (1995).
  10. ^ "Chemical and Biological Weapons: Possession and Programs Past and Present", James Martin Center for Nonproliferation Studies, Middlebury College, April 9, 2002, accessed November 14, 2008.
  11. ^ Alibek, Ken and Steven Handelman (1999), Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World - Told from Inside by the Man Who Ran It, Random House, ISBN 0-385-33496-6.

Bibliography

  • Kilgore PE, Peters CJ, Mills JN; et al. (1995). "Prospects for the control of Bolivian hemorrhagic fever". Emerging Infect. Dis. 1 (3): 97–100.  

[1]

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.