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Title: Auxotrophy  
Author: World Heritage Encyclopedia
Language: English
Subject: Bradytroph, Ames test, Molecular genetics, Selectable marker, Bioreactor
Collection: Molecular Genetics
Publisher: World Heritage Encyclopedia


Auxotrophy (IUPAC). An auxotroph is an organism that displays this characteristic; auxotrophic is the corresponding adjective. Auxotrophy is the opposite of prototrophy, which is characterized by the ability to synthesize all the compounds needed for growth.

The method of replica plating implemented by Esther Lederberg included auxotrophs that were temperature-sensitive; that is, their ability to synthesize was temperature-dependent. (Auxotrophs are usually not temperature-dependent. They can also depend on other factors.) Multiple auxotrophs can also coexist at the same time, within the same organism.

In Beadle and Tatum's Nobel prize-winning work on the one gene-one enzyme hypothesis.

Researchers have used strains of E. coli auxotrophic for specific amino acids to introduce non-natural amino acid analogues into proteins. For instance cells auxotrophic for the amino acid phenylalanine can be grown in media supplemented with an analogue such as para-azido phenylalanine.

Many living things, including humans, are auxotrophic for large classes of compounds required for growth and must obtain these compounds through diet (see vitamin, essential nutrient, essential amino acid, essential fatty acid).

The complex pattern of evolution of vitamin auxotrophy across the


  • "Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8" - The EMBO Journal
  • "Pleiotropic effects of purine auxotrophy inRhizobium meliloti on cell surface molecules" - Springerlink
  • "Auxotrophy and Organic Compounds in the Nutrition of Marine Phytoplankton"

External links

See also

  1. ^ Helliwell, Katherine E. et al. (2013). Widespread decay of vitamin-related pathways: coincidence or consequence?. Trends in Genetics, Volume 29, Issue 8, 469-478



  • Footnotes 1
  • See also 2
  • External links 3
  • References 4


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