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Title: Globoside  
Author: World Heritage Encyclopedia
Language: English
Subject: Transfusion medicine, Glycolipids, Glucocerebroside, Galactocerebroside, GM2 (ganglioside)
Collection: Glycolipids
Publisher: World Heritage Encyclopedia


A globoside is a type of glycosphingolipid with more than one sugar as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. A glycosphingolipid that has only one sugar as the side chain is called a cerebroside.

The side chain can be cleaved by galactosidases and glucosidases. The deficiency of α-galactosidase A causes Fabry's disease, an inherited metabolic disease characterized by the accumulation of the globoside globotriaosylceramide.

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