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Centromere protein E

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Title: Centromere protein E  
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Subject: Telomere-binding protein, DbCRID, CENPI, CENPC1, CENPO
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Centromere protein E

Centromere protein E, 312kDa

PDB rendering based on 1t5c.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CENP-E; KIF10; PPP1R61
External IDs ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.[1][2] Centromere-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.[2]

References

  1. ^ Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics 23 (3): 691–3.  
  2. ^ a b "Entrez Gene: CENPE centromere protein E, 312kDa". 

Further reading


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