World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0014881616
Reproduction Date:

Title: Cenph  
Author: World Heritage Encyclopedia
Language: English
Subject: Telomere-binding protein, CENPF, CENPC1, CENPO, CENPT
Publisher: World Heritage Encyclopedia


Centromere protein H
Symbols  ; NNF1; PMF1
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search
Symbol CENP-H
Pfam PF05837
InterPro IPR008426

Centromere protein H is a protein that in humans is encoded by the CENPH gene.[1][2][3]


[5] CENP-H contains a coiled-coil structure and a nuclear localisation signal.[5]

Studies show that CENP-H may be associated with certain human cancers.[6][7]

CENP-H shows sequence similarity to the Schizosaccharomyces pombe kinetochore protein Fta3 which is a subunit of the Sim4 complex. This complex is required for loading the DASH complex onto the kinetochore via interaction with dad1. Fta2, Fta3 and Fta4 associate with the central core and inner repeat region of the centromere.[8]

Other Protein Interactions

CENPH has also been shown to interact with KIAA0090.[9] The significance of this interaction is unclear.


  1. ^
  2. ^
  3. ^
  4. ^
  5. ^ a b
  6. ^
  7. ^
  8. ^
  9. ^

Further reading

This article incorporates text from the public domain Pfam and InterPro IPR008426

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.