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Braun's lipoprotein

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Title: Braun's lipoprotein  
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Subject: Lipoproteins, BLP, Bacterial outer membrane, Peripheral membrane proteins, Gram-negative bacteria
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Braun's lipoprotein

Braun's lipoprotein (BLP or Murein Lipoprotein), found in some gram-negative cell walls, is one of the most abundant membrane proteins; its molecular weight is about 7.2 kDa. It is bound at its C-terminal end (a lysine) by a covalent bond to the peptidoglycan layer (specifically to diaminopimelic acid molecules[1]) and is embedded in the outer membrane by its hydrophobic head (a cysteine with lipids attached). BLP tightly links the two layers and provides structural integrity to the outer membrane.

Braun's Lipoprotein consists of phospholipids and Lipopolysaccharide.

References

  1. ^ Seltmann, Guntram; Holst, Otto (2002). The Bacterial Cell Wall. Berlin: Springer. pp. 81–82.  

°Mogensen, T. H. (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22, 240-273 Van Amersfoort, E. S., Van Berkel, T. J., and Kuiper, J. (2003) Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev 16, 379-414 Neilsen, P. O., Zimmerman, G. A., and McIntyre, T. M. (2001) Escherichia coli Braun lipoprotein induces a lipopolysaccharide-like endotoxic response from primary human endothelial cells. J Immunol 167, 5231-5239

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