Guidelines for Air Sampling and Analytical Method Development and Evaluation

By Kennedy, Eugene R.

Book Id: WPLBN0000123840
Format Type: PDF eBook:
File Size: 4.76 MB
Reproduction Date: 2005

Title:	Guidelines for Air Sampling and Analytical Method Development and Evaluation
Author:	Kennedy, Eugene R.
Volume:
Language:	English
Subject:	Health., Medical research, Medical reports
Collections:	Medical Library Collection
Historic Publication Date:
Publisher:	Centers for Disease Control and Prevention


Citation APA MLA Chicago R. Kenned, B. E. (n.d.). Guidelines for Air Sampling and Analytical Method Development and Evaluation. Retrieved from http://gutenberg.us/

Excerpt
The Occupational Safety and Health Act of 1970 (Public Law 91-596) charged the National Institute for Occupational Safety and Health (NIOSH) with the responsibility for the development and evaluation of sampling and analytical methods for workplace compliance determinations. Under that charge, NIOSH and the Occupational Safety and Health Administration jointly undertook the evaluation of sampling and analytical methods for airborne contaminants by contract in 1974 to determine if methods met the criterion to produce a result that falls within 25% of the true value 95 times out of 100. This guideline document further expands the experimental protocol used during this initial methods development and evaluation research.

Table of Contents
CONTENTS ABSTRACT .................................................................... iii ACKNOWLEDGMENTS .......................................................... iv I . INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 A . Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 B . Definitions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1 . Accuracy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 . Precision . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 3 . Bias . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4 . Limit Of Detection and Limit Of Quantitation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 5 . Measurement Range . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 6 . Evaluation Range . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 7 . Estimated Recovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 8 . Interferences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 9 . Capacity (Breakthrough) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 10 . Sampling Rate or Uptake Rate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 11 . Exposure Limit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 12 . Sample Stability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4 I1. METHOD DEVELOPMENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5 A. Analyte Identification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 B. Literature Search . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1 . Measurement and evaluation concentration ranges . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2 . Physical and chemical properties . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3 . Information about the use of the analyte . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 4 . Method availability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 C . Experimental . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 1 . Analysis procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2 . Sampling procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 111 . METHOD EVALUATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 A . Recovery of the analyte from the medium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1 . Experimental . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2 . Criterion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 B . Stability of analyte on the sampling medium ................................. 11 C . Stability of the sampling medium . . . . . . . . . . . . . . . . . . . . . . . . . . . . .