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Mafp

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Subject: Diisopropyl fluorophosphate, Fatty acid amide hydrolase, Activity-based proteomics
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Mafp

Methoxy arachidonyl fluorophosphonate
Identifiers
PubChem 10429254
ChemSpider 8604682 YesY
Jmol-3D images Image 1
Properties
Molecular formula C21H36FO2P
Molar mass 370.5
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases.[1] It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC50 values in the low-nanomolar range.

See also

  • DIFP - diisopropyl fluorophosphate, a related inhibitor
  • IDFP - isopropyl dodecylfluorophosphonate, another related inhibitor with selectivity for FAAH and MAGL
  • Activity based probes

References


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